Leukaemic stem cell load at diagnosis predicts the development of relapse in young acute myeloid leukaemia patients

Diana Hanekamp¹, Barbara Denys², Gertjan J L Kaspers^{3

4}, Jeroen G Te Marvelde⁵, Gerrit Jan Schuurhuis¹, Valerie De Haas⁶, Barbara De Moerloose^{7

8}, Eveline S de Bont⁹, C Michel Zwaan¹⁰, Anja de Jong⁶, Barbara Depreter^{7

8

11}, Tim Lammens^{7

8}, Jan Philippé^{2

8

11}, Jacqueline Cloos^{1

3}, Vincent H J van der Velden⁵

Affiliations

¹ Department of Haematology, VU University Medical Center, Amsterdam, the Netherlands.
² Department of Laboratory Medicine, Haematology, Ghent University Hospital, Ghent, Belgium.
³ Department of Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, the Netherlands.
⁴ Princess Máxima Center for Paediatric Oncology, Utrecht, the Netherlands.
⁵ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
⁶ Dutch Childhood Oncology Group, The Hague, the Netherlands.
⁷ Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
⁸ Cancer Research Institute Ghent, Ghent, Belgium.
⁹ Department of Paediatric Oncology/Haematology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
¹⁰ Department of Paediatric Oncology/Haematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
¹¹ Department of Clinical Biology, Microbiology and Immunology, Ghent University, Ghent, Belgium.

Diana Hanekamp et al. Br J Haematol. 2018 Nov.

. 2018 Nov;183(3):512-516.

doi: 10.1111/bjh.14991. Epub 2017 Oct 26.

¹ Department of Haematology, VU University Medical Center, Amsterdam, the Netherlands.
² Department of Laboratory Medicine, Haematology, Ghent University Hospital, Ghent, Belgium.
³ Department of Paediatric Oncology/Haematology, VU University Medical Center, Amsterdam, the Netherlands.
⁴ Princess Máxima Center for Paediatric Oncology, Utrecht, the Netherlands.
⁵ Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
⁶ Dutch Childhood Oncology Group, The Hague, the Netherlands.
⁷ Department of Paediatric Haematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.
⁸ Cancer Research Institute Ghent, Ghent, Belgium.
⁹ Department of Paediatric Oncology/Haematology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
¹⁰ Department of Paediatric Oncology/Haematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
¹¹ Department of Clinical Biology, Microbiology and Immunology, Ghent University, Ghent, Belgium.

No abstract available

Keywords: flow cytometry; immunophenotyping; leukaemic stem cells; paediatric acute myeloid leukaemia; prognosis.

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