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. 1988:240:207-14.
doi: 10.1007/978-1-4613-1057-0_25.

Characterization of different forms of dipeptidyl peptidase IV from rat liver and hepatoma by monoclonal antibodies

S Hartel  1 , C Hanski, R Neumeier, R Gossrau, W Reutter
Affiliations

Characterization of different forms of dipeptidyl peptidase IV from rat liver and hepatoma by monoclonal antibodies

S Hartel et al. Adv Exp Med Biol. 1988.

Abstract

Nine monoclonal antibodies directed against DPP IV from rat liver plasma membranes were obtained. They recognized four different epitopes (A, B, C and D) of the enzyme. The epitopes A, B and C were located on the outside of the hepatocyte plasma membrane and were shared by DPP IV from hepatoma plasma membrane and the soluble form. Epitope D appeared to be partly inserted in the membrane and was found exclusively in the liver. Epitopes A, B and C and DPP IV revealed by histochemical means showed similar distribution patterns on frozen sections of various rat tissues, while epitope D did not show such a correlation. DPP IV is inserted in liver plasma membrane by two different mechanisms, one being phospholipase C-sensitive, while in hepatoma the enzyme is anchored in this membrane by a phospholipase C-resistant mechanism only.

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