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Review
. 2017 Oct;354(4):335-338.
doi: 10.1016/j.amjms.2017.02.008. Epub 2017 Mar 2.

Secondary Hyperparathyroidism in Heart Failure

Mohamed S Morsy  1 , Dwight A Dishmon  1 , Nadish Garg  1 , Karl T Weber  2
Affiliations
Review

Secondary Hyperparathyroidism in Heart Failure

Mohamed S Morsy et al. Am J Med Sci. 2017 Oct.

Abstract

Secondary hyperparathyroidism (SHPT) is a well-known pathophysiologic feature of chronic renal failure. In recent years, SHPT has become recognized as a complication of the aldosteronism associated with congestive heart failure and where excretory Ca2+ and Mg2+ wasting results in plasma-ionized hypocalcemia and hypomagnesemia. Elevations in plasma parathyroid hormone have adverse systemic consequences, including intracellular Ca2+ overloading of myocytes and vascular smooth muscle with the induction of oxidative stress. Herein, we briefly review the presence and adverse outcomes of SHPT in persons with heart failure.

Keywords: Heart failure; Hypocalcemia; Hypomagnesemia; Secondary hyperparathyroidism.

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