Hepatitis C Virus Infection in the Older Patient

doi:10.1016/j.idc.2017.07.014

Review

. 2017 Dec;31(4):827-838.

doi: 10.1016/j.idc.2017.07.014.

Hepatitis C Virus Infection in the Older Patient

Michael Reid¹, Jennifer C Price¹, Phyllis C Tien²

Affiliations

¹ Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA.
² Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA; Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA 94121, USA. Electronic address: phyllis.tien@ucsf.edu.

PMID: 29079161
PMCID: PMC5675560
DOI: 10.1016/j.idc.2017.07.014

Review

Hepatitis C Virus Infection in the Older Patient

Michael Reid et al. Infect Dis Clin North Am. 2017 Dec.

. 2017 Dec;31(4):827-838.

doi: 10.1016/j.idc.2017.07.014.

Authors

Michael Reid¹, Jennifer C Price¹, Phyllis C Tien²

Affiliations

¹ Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA.
² Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94122, USA; Medical Service, Department of Veteran Affairs Medical Center, San Francisco, CA 94121, USA. Electronic address: phyllis.tien@ucsf.edu.

PMID: 29079161
PMCID: PMC5675560
DOI: 10.1016/j.idc.2017.07.014

Abstract

Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is of concern in older adults. HCV infection is associated with not only hepatic but also extrahepatic comorbidities common to the aging patient including diabetes, kidney and cardiovascular diseases, and neurocognitive impairment. The effect of direct-acting antiviral agents to treat HCV on these outcomes is limited. This article summarizes the literature regarding the epidemiology and natural history of HCV infection; the impact of age on clinical outcomes in HCV-infected persons; and current knowledge regarding safety and efficacy of HCV treatment regimens in the older patient.

Keywords: Aging; Comorbidity; HCV; Inflammation.

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Figures

**Figure**
Natural history and clinical course of HCV infection

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References

1. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–714. - PubMed
1. Rein DB, Smith BD, Wittenborn JS, et al. The cost-effectiveness of birth-cohort screening for hepatitis C antibody in U.S. primary care settings. Ann Intern Med. 2012;156(4):263–270. - PMC - PubMed
1. Suryaprasad AG, White JZ, Xu F, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006–2012. Clin Infect Dis. 2014;59(10):1411–1419. - PubMed
1. Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. MMWR Recomm Rep. 2012;61(RR-4):1–32. - PubMed
1. Smith BD, Beckett GA, Yartel A, Holtzman D, Patel N, Ward JW. Previous exposure to HCV among persons born during 1945–1965: prevalence and predictors, United States, 1999–2008. Am J Public Health. 2014;104(3):474–481. - PMC - PubMed

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[1] Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–714. - PubMed

[2] Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med. 2006;144(10):705–714. - PubMed

[3] Rein DB, Smith BD, Wittenborn JS, et al. The cost-effectiveness of birth-cohort screening for hepatitis C antibody in U.S. primary care settings. Ann Intern Med. 2012;156(4):263–270. - PMC - PubMed

[4] Rein DB, Smith BD, Wittenborn JS, et al. The cost-effectiveness of birth-cohort screening for hepatitis C antibody in U.S. primary care settings. Ann Intern Med. 2012;156(4):263–270. - PMC - PubMed

[5] Suryaprasad AG, White JZ, Xu F, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006–2012. Clin Infect Dis. 2014;59(10):1411–1419. - PubMed

[6] Suryaprasad AG, White JZ, Xu F, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006–2012. Clin Infect Dis. 2014;59(10):1411–1419. - PubMed

[7] Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. MMWR Recomm Rep. 2012;61(RR-4):1–32. - PubMed

[8] Smith BD, Morgan RL, Beckett GA, et al. Recommendations for the identification of chronic hepatitis C virus infection among persons born during 1945–1965. MMWR Recomm Rep. 2012;61(RR-4):1–32. - PubMed

[9] Smith BD, Beckett GA, Yartel A, Holtzman D, Patel N, Ward JW. Previous exposure to HCV among persons born during 1945–1965: prevalence and predictors, United States, 1999–2008. Am J Public Health. 2014;104(3):474–481. - PMC - PubMed

[10] Smith BD, Beckett GA, Yartel A, Holtzman D, Patel N, Ward JW. Previous exposure to HCV among persons born during 1945–1965: prevalence and predictors, United States, 1999–2008. Am J Public Health. 2014;104(3):474–481. - PMC - PubMed

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Hepatitis C Virus Infection in the Older Patient

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Hepatitis C Virus Infection in the Older Patient

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