Clinical study on clinical operation and post-treatment reactions of HMME-PDT in treatment of PWS

Abstract

Objective: To analyze the clinical efficacy of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating port-wine stains (PWS), and its clinical operation skills and operation essentials.

Method: A total of 16 cases of PWS with negative HMME skin test results were included in this study. Their treated areas were exposed and injected with 5mg/kg HMME, and then irradiated under 532nm LED green light (produced by Wuhan YaGe LED1 modified machines), with the irradiation power density between 80 and 100mW/cm². Each light spot was irradiated for 20-25min. After one treatment, the clinical efficacy and post-treatment reactions at each treated area were observed.

Result: Under standard operation, two of the 16 cases were cured (12.5%) after one HMME-PDT treatment, eight cases indicates a good efficacy (50.0%), four cases showed alleviation (25.0%), while two cases displayed no efficacy (12.5%), indicating an one-time response rate of 87.5%. Pain was reported during treatment, and significant post-treatment edema was observed at the treated areas; And no allergy or other adverse reaction were reported.

Conclusion: In adherence to operation standards and operation essentials during treatment, HMME-PDT shows a satisfactory clinical efficacy in treating PWS.

Keywords: Hematoporphyrin monomethyl ether; Photodynamic therapy; Port-wine stain.