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. 2018 Jan;103(1):e17-e20.
doi: 10.3324/haematol.2017.180497. Epub 2017 Oct 27.

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

Frank G Rücker  1 , Anna Dolnik  2 , Tamara J Blätte  2 , Veronica Teleanu  2 , Aurélie Ernst  3 , Felicitas Thol  4 , Michael Heuser  4 , Arnold Ganser  4 , Hartmut Döhner  2 , Konstanze Döhner  2 , Lars Bullinger  2   5
Affiliations

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype

Frank G Rücker et al. Haematologica. 2018 Jan.
No abstract available

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Figures

Figure 1.
Figure 1.
Chromothripsis in CK-AML. (A) Pie chart illustrating the chromosomal distribution of patterns of chromothripsis identified in 39 of 112 CK-AML patients. (B) Network diagram of genomic complexity in 112 CK-AML: cases with chromothripsis are numbered from 1 to 39 (highlighted in white), cases without chromothripsis are numbered from 40 to 112 (highlighted in gray). Aberrations are indicated as the absolute count per each individual case: the green line indicates number of losses, the red line the number of gains, the light red line the number of amplifications, and the blue line the total numbers of aberrations. (C) Kaplan-Meier survival estimate according to chromothripsis in CK-AML. Overall survival is shown for chromothripsis-negative(-) CK-AML (n=46) and chromothripsis-positive(+) CK-AML (n=16) (months; log-rank test). (D) Gene expression data for chromothripsis-positive (n=13) vs. –negative (n=14) CK-AML (left panels) and chromothripsis-positive (n=10) vs. –negative (n=7) TP53altered CK-AML cases (right panels). Upper panel: volcano plots of all 421 (left) and 337 (right) significantly differentially expressed genes in terms of their measured expression change (x-axis) and the significance of their change (y-axis). The most significantly down- and upregulated genes are indicated. Lower panel: the top significantly impacted pathways are plotted in terms of over-representation on the x-axis (pORA) and total pathway accumulation on the y-axis (pAcc). Each pathway is represented by a single dot, and the size of each dot is proportional to the size of the pathway it represents. P-values are shown in negative log (base 10) values. CK-AML: complex karyotype acute myeloid leukemia.
See this image and copyright information in PMC

References

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