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Review
. 2017 Dec;46(4):1009-1038.
doi: 10.1016/j.ecl.2017.07.007. Epub 2017 Sep 29.

Vitamin D Receptor Signaling and Cancer

Moray J Campbell  1 , Donald L Trump  2
Affiliations
Review

Vitamin D Receptor Signaling and Cancer

Moray J Campbell et al. Endocrinol Metab Clin North Am. 2017 Dec.

Abstract

The vitamin D receptor (VDR) binds the secosteroid hormone 1,25(OH)2D3 with high affinity and regulates gene programs that control a serum calcium levels, as well as cell proliferation and differentiation. A significant focus has been to exploit the VDR in cancer settings. Although preclinical studies have been strongly encouraging, to date clinical trials have delivered equivocal findings that have paused the clinical translation of these compounds. However, it is entirely possible that mining of genomic data will help to refine precisely what are the key anticancer actions of vitamin D compounds and where these can be used most effectively.

Keywords: Chemoprevention; Chemotherapy; Genomics; TCGA; Vitamin D.

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