Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

Erika Roddy¹, Malcolm R DeBaun², Adam Daoud-Gray³, Yunzhi P Yang^{4

5

6}, Michael J Gardner⁷

Affiliations

¹ School of Medicine, University of California, San Francisco (UCSF), 513 Parnassus Ave, San Francisco, CA, 94143, USA.
² Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
³ School of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁴ Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁵ Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA, 94305, USA.
⁶ Department of Materials Science and Engineering, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁷ Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA. michaelgardner@stanford.edu.

PMID: 29080923
DOI: 10.1007/s00590-017-2063-0

Review

Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

Erika Roddy et al. Eur J Orthop Surg Traumatol. 2018 Apr.

. 2018 Apr;28(3):351-362.

doi: 10.1007/s00590-017-2063-0. Epub 2017 Oct 28.

Authors

Erika Roddy¹, Malcolm R DeBaun², Adam Daoud-Gray³, Yunzhi P Yang^{4

5

6}, Michael J Gardner⁷

Affiliations

¹ School of Medicine, University of California, San Francisco (UCSF), 513 Parnassus Ave, San Francisco, CA, 94143, USA.
² Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
³ School of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁴ Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁵ Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, CA, 94305, USA.
⁶ Department of Materials Science and Engineering, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA.
⁷ Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, CA, 94305, USA. michaelgardner@stanford.edu.

PMID: 29080923
DOI: 10.1007/s00590-017-2063-0

Abstract

Critical-sized bone defects are defined as those that will not heal spontaneously within a patient's lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects.

Keywords: Bone healing; Bone tissue engineering; Critical bone defects; Fracture healing.

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References

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1. J Orthop Trauma. 2007 Mar;21(3):192-7 - PubMed
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Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

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Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

Authors

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Abstract

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Medical