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. 2017 Jul-Sep;8(3):132-133.
doi: 10.4103/jpp.JPP_37_17.

Cardiac Safety of High-dose Micafungin

Kayla R Stover  1 , John D Cleary  2
Affiliations

Cardiac Safety of High-dose Micafungin

Kayla R Stover et al. J Pharmacol Pharmacother. 2017 Jul-Sep.
No abstract available

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Conflict of interest statement

Both authors have received grant funding from Astellas US Pharma, Inc.

Figures

Figure 1
Figure 1
Cardiac output with high-dose micafungin (10–50 mg/kg) compared to saline control. Preventilation measurements of cardiac output are represented as a percent change from baseline relative to time (20 min antifungal infusion and 30 min observation period). Values represent mean cardiac output decrease from baseline ± standard deviation
See this image and copyright information in PMC

References

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    1. Stover KR, Farley JM, Kyle PB, Cleary JD. Cardiac toxicity of some echinocandin antifungals. Expert Opin Drug Saf. 2014;13:5–14. - PubMed
    1. Stover KR, Cleary JD. Cardiac response to centrally administered echinocandin antifungals. J Pharm Pharmacol. 2015;67:1279–83. - PubMed
    1. Koch C, Uhle F, Wolff M, Arens C, Schulte A, Li L, et al. Cardiac effects of echinocandins after central venous administration in adult rats. Antimicrob Agents Chemother. 2015;59:1612–9. - PMC - PubMed
    1. Stover KR, King ST, Cleary JD. Cardiac toxicity of the echinocandins: Chance or cause and effect association? J Clin Pharm Ther. 2014;39:1–3. - PubMed

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