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Clinical Trial
. 1988 Aug:153:208-13.
doi: 10.1192/bjp.153.2.208.

A clinical trial of the efficacy and acceptability of D-fenfluramine in the treatment of neuroleptic-induced obesity

E Goodall  1 , C Oxtoby, R Richards, G Watkinson, D Brown, T Silverstone
Affiliations
Clinical Trial

A clinical trial of the efficacy and acceptability of D-fenfluramine in the treatment of neuroleptic-induced obesity

E Goodall et al. Br J Psychiatry. 1988 Aug.

Abstract

Twenty-nine overweight schizophrenic patients maintained on depot neuroleptic injections who wished to lose weight took part in a double-blind, placebo-controlled trial of 30 mg D-fenfluramine. All subjects received dietary advice. Sixteen patients completed the 12-week trial. Rate of weight loss was significantly greater in those taking D-fenfluramine. Side-effects were reported, but no deterioration in mental state was noted.

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