Prurigo Nodularis
- PMID: 29083653
- Bookshelf ID: NBK459204
Prurigo Nodularis
Excerpt
Prurigo nodularis (PN) is a chronic disorder of the skin that is classically seen as multiple, firm, flesh-to-pink-colored nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic, and the condition may occur in any age group. It is commonly associated with another disorder of cutaneous hypersensitivity, such as atopic dermatitis or chronic pruritus of diverse origins. The diagnosis is mainly clinical, although certain conditions may simulate it clinically, warranting differentiation. The condition is associated with significant physical and psychological morbidity and is often refractory to treatments. A wide range of general measures, pharmacological approaches, and psychological therapies may be needed in a patient with advanced PN.
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Sections
- Continuing Education Activity
- Introduction
- Etiology
- Epidemiology
- Pathophysiology
- Histopathology
- History and Physical
- Evaluation
- Treatment / Management
- Differential Diagnosis
- Treatment Planning
- Prognosis
- Complications
- Deterrence and Patient Education
- Pearls and Other Issues
- Enhancing Healthcare Team Outcomes
- Review Questions
- References
References
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- Harbaoui S, Litaiem N. StatPearls [Internet] StatPearls Publishing; Treasure Island (FL): 2023. Feb 13, Acquired Perforating Dermatosis. - PubMed
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- Ständer S, Kwon P, Hirman J, Perlman AJ, Weisshaar E, Metz M, Luger TA, TCP-102 Study Group Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial. J Am Acad Dermatol. 2019 May;80(5):1395-1402. - PubMed
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- Iking A, Grundmann S, Chatzigeorgakidis E, Phan NQ, Klein D, Ständer S. Prurigo as a symptom of atopic and non-atopic diseases: aetiological survey in a consecutive cohort of 108 patients. J Eur Acad Dermatol Venereol. 2013 May;27(5):550-7. - PubMed
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