Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Narcolepsy

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Narcolepsy

Jennifer M. Slowik et al.
Free Books & Documents

Excerpt

Narcolepsy is a disorder of rapid onset rapid eye movement (REM) sleep characterized by excessive daytime sleepiness (EDS), frequent uncontrollable sleep attacks as well as sleep fragmentation and can be associated with cataplexy, sleep paralysis, and hypnagogic hallucinations. There are two types: narcolepsy type 1 (formerly narcolepsy with cataplexy) and narcolepsy type 2 (formerly narcolepsy without cataplexy).

The condition is often under-diagnosed and delays of 5-10 years are common before making a firm diagnosis. Close to 50% of patients develop symptoms in their teenage years. The disorder has enormous morbidity leading to impairment in academic and social performance. The condition, fortunately, does respond to treatment.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Jennifer Slowik declares no relevant financial relationships with ineligible companies.

Disclosure: Jacob Collen declares no relevant financial relationships with ineligible companies.

Disclosure: Allison Yow declares no relevant financial relationships with ineligible companies.

References

    1. Scammell TE. Narcolepsy. N Engl J Med. 2015 Dec 31;373(27):2654-62. - PubMed
    1. Mignot E, Hayduk R, Black J, Grumet FC, Guilleminault C. HLA DQB1*0602 is associated with cataplexy in 509 narcoleptic patients. Sleep. 1997 Nov;20(11):1012-20. - PubMed
    1. Ahmed SS, Schur PH, MacDonald NE, Steinman L. Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: what is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants. J Autoimmun. 2014 May;50:1-11. - PubMed
    1. Sarkanen T, Alakuijala A, Julkunen I, Partinen M. Narcolepsy Associated with Pandemrix Vaccine. Curr Neurol Neurosci Rep. 2018 Jun 01;18(7):43. - PubMed
    1. Aran A, Lin L, Nevsimalova S, Plazzi G, Hong SC, Weiner K, Zeitzer J, Mignot E. Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. Sleep. 2009 Aug;32(8):979-83. - PMC - PubMed

Publication types

LinkOut - more resources