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Book

Influenza

In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
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Book

Influenza

Sameh W. Boktor et al.
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Excerpt

Influenza is a communicable viral disease that affects the upper and lower respiratory tract. A wide spectrum of influenza viruses causes it. Some of these viruses can infect humans, and some are specific to different species. These viruses are transmissible through respiratory droplets expelled from the mouth and respiratory system during coughing, talking, and sneezing. The influenza viruses can be transmitted by touching inanimate objects soiled with the virus and touching the nose or eye. Influenza can be transmitted before the patient is symptomatic and until 5 to 7 days after infection. After infection, it takes a few days for most of the healthy patients to recover fully, but complications that include pneumonia and death are common in certain high-risk groups. These groups include young children, the elderly, immunocompromised, and pregnant females. Symptoms of influenza include a runny nose, high fever, cough, and sore throat. Influenza spreads rapidly and efficiently in seasonal epidemics. Flu epidemics occur every autumn and winter in temperate regions and affect a significant portion of adults and children, but seasons differently impact age groups and severity.

Over the past few decades, more lethal strains of the influenza virus have evolved. Besides infecting humans, these viruses also infect animals. Clinicians should be aware that all rapid tests for detecting influenza have limited sensitivity, and false-negative results are common. The gold standard for diagnosis is the polymerase chain reaction test or viral culture of throat secretions, but these tests take a few days to yield results. The key strategy in reducing the morbidity of the infection is vaccination.

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Conflict of interest statement

Disclosure: Sameh Boktor declares no relevant financial relationships with ineligible companies.

Disclosure: John Hafner declares no relevant financial relationships with ineligible companies.

References

    1. Alguacil-Ramos AM, Portero-Alonso A, Pastor-Villalba E, Muelas-Tirado J, Díez-Domingo J, Sanchis-Ferrer A, Lluch-Rodrigo JA. Rapid assessment of enhanced safety surveillance for influenza vaccine. Public Health. 2019 Mar;168:137-141. - PubMed
    1. Tennant RK, Holzer B, Love J, Tchilian E, White HN. Higher levels of B-cell mutation in the early germinal centres of an inefficient secondary antibody response to a variant influenza haemagglutinin. Immunology. 2019 May;157(1):86-91. - PMC - PubMed
    1. Marshall C, Williams K, Matchett E, Hobbs L. Sustained improvement in staff influenza vaccination rates over six years without a mandatory policy. Infect Control Hosp Epidemiol. 2019 Mar;40(3):389-390. - PubMed
    1. Odun-Ayo F, Odaibo G, Olaleye D. Influenza virus A (H1 and H3) and B co-circulation among patient presenting with acute respiratory tract infection in Ibadan, Nigeria. Afr Health Sci. 2018 Dec;18(4):1134-1143. - PMC - PubMed
    1. Havlickova M, Druelles S, Jirincova H, Limberkova R, Nagy A, Rasuli A, Kyncl J. Circulation of influenza A and B in the Czech Republic from 2000-2001 to 2015-2016. BMC Infect Dis. 2019 Feb 14;19(1):160. - PMC - PubMed

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