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Book

Glipizide

Ricardo Correa  1 , Preeti Patel, Thomas M. Nappe  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Book

Glipizide

Ricardo Correa et al.
Free Books & Documents

Excerpt

Glipizide is a second-generation sulfonylurea widely used in the management of type 2 diabetes. It remains an important therapeutic option for improving glycemic control in adults requiring pharmacologic therapy in addition to diet and exercise. As an insulin secretagogue, glipizide enhances pancreatic beta-cell insulin release and may modestly reduce hepatic glucose output, contributing to adequate glucose lowering. Although generally well tolerated, glipizide carries clinically relevant risks, including hypoglycemia, weight gain, and drug-drug interactions that may potentiate or diminish its therapeutic effect. These considerations underscore the need for careful patient selection, ongoing monitoring, and interprofessional coordination.

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Conflict of interest statement

Disclosure: Ricardo Correa declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Thomas Nappe declares no relevant financial relationships with ineligible companies.

References

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