DNA Damage Repair System in Plants: A Worldwide Research Update

Abstract

Living organisms are usually exposed to various DNA damaging agents so the mechanisms to detect and repair diverse DNA lesions have developed in all organisms with the result of maintaining genome integrity. Defects in DNA repair machinery contribute to cancer, certain diseases, and aging. Therefore, conserving the genomic sequence in organisms is key for the perpetuation of life. The machinery of DNA damage repair (DDR) in prokaryotes and eukaryotes is similar. Plants also share mechanisms for DNA repair with animals, although they differ in other important details. Plants have, surprisingly, been less investigated than other living organisms in this context, despite the fact that numerous lethal mutations in animals are viable in plants. In this manuscript, a worldwide bibliometric analysis of DDR systems and DDR research in plants was made. A comparison between both subjects was accomplished. The bibliometric analyses prove that the first study about DDR systems in plants (1987) was published thirteen years later than that for other living organisms (1975). Despite the increase in the number of papers about DDR mechanisms in plants in recent decades, nowadays the number of articles published each year about DDR systems in plants only represents 10% of the total number of articles about DDR. The DDR research field was done by 74 countries while the number of countries involved in the DDR & Plant field is 44. This indicates the great influence that DDR research in the plant field currently has, worldwide. As expected, the percentage of studies published about DDR systems in plants has increased in the subject area of agricultural and biological sciences and has diminished in medicine with respect to DDR studies in other living organisms. In short, bibliometric results highlight the current interest in DDR research in plants among DDR studies and can open new perspectives in the research field of DNA damage repair.

Keywords: DNA damage repair; Scopus; bibliometric; plant; worldwide.

Figure 1

Trends in publications in the DNA damage repair (DDR) research field and the DDR research in plant field from 1975–2016.

Figure 2

Distribution (%) of worldwide research on: (a) DDR and (b) DDR & Plant by subject area, as classified by Scopus.

Figure 3

Worldwide research on DDR and DDR & Plant during the period 1970–2016.

Figure 4

Cloud word based on the main keywords related to worldwide DDR (a) and DDR & Plant (b) research.

Figure 5

Top ten keywords and Plant keyword evolution related to worldwide DDR research (2006–2016).

Figure 6

Distribution of main keywords by country as percentage of their own publications.