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Review
. 2018 Jan 2;90(1):556-576.
doi: 10.1021/acs.analchem.7b04247. Epub 2017 Nov 7.

Chemical Analysis of DNA Damage

Yang Yu  1 , Pengcheng Wang  1 , Yuxiang Cui  1 , Yinsheng Wang  1
Affiliations
Review

Chemical Analysis of DNA Damage

Yang Yu et al. Anal Chem. .
No abstract available

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Conflict of interest statement

Notes

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Chemical structures of selected ROS- and lipid peroxidation byproduct-induced DNA lesions.
Figure 2
Figure 2
Chemical structures of selected alkylated DNA lesions.
Figure 3
Figure 3
Chemical structures of DNA lesions induced by tobacco-specific nitrosamines.
Figure 4
Figure 4
Chemical structures of selected DNA lesions induced by polycyclic aromatic hydrocarbons.
Figure 5
Figure 5
Chemical structures of selected DNA lesions induced by chemotherapeutic drugs.
Figure 6
Figure 6
Chemical structures of selected DNA lesions induced by food-related chemical carcinogens, herbal plant secondary metabolites, and heterocyclic aromatic amines.
Figure 7
Figure 7
Next-generation sequencing for mapping the genome-wide distributions of DNA lesions.
Figure 8
Figure 8
Schematic diagrams showing the experimental procedures for the competitive replication and adduct bypass assay in E. coli cells (a) and mammalian cells (b).
Figure 9
Figure 9
A scheme outlining the experimental procedures of the competitive transcription and adduct bypass assay.
Figure 10
Figure 10
Overall procedures of the in vivo replication assay using next-generation sequencing.
See this image and copyright information in PMC

References

    1. Bauer NC, Corbett AH, Doetsch PW. Nucleic Acids Res. 2015;43:10083–10101. - PMC - PubMed
    1. Chatterjee N, Walker GC. Environ Mol Mutag. 2017;58:235–263. - PMC - PubMed
    1. Delaney JC, Essigmann JM. Chem Res Toxicol. 2008;21:232–252. - PMC - PubMed
    1. You C, Wang Y. Acc Chem Res. 2016;49:205–213. - PMC - PubMed
    1. Finkel T, Holbrook NJ. Nature. 2000;408:239–247. - PubMed

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