Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jan 15;24(2):253-255.
doi: 10.1158/1078-0432.CCR-17-2823. Epub 2017 Oct 30.

Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?

John F Marshall  1
Affiliations
Comment

Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?

John F Marshall. Clin Cancer Res. .

Abstract

Cadherin-17 (CDH17) has been implicated as protumorigenic for many years, but mechanisms have been unclear. A Spanish team has generated antibodies to an RGD motif in CDH17 that inhibits integrin α2β1 binding to CDH17 and thereby inhibits integrin activation, tumorigenesis, and metastasis. These reagents may have therapeutic potential. Clin Cancer Res; 24(2); 253-5. ©2017 AACRSee related article by Bartolomé et al., p. 433.

PubMed Disclaimer

Comment on

Publication types

LinkOut - more resources