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Practice Guideline
. 2018 Jan;20(1):22-28.
doi: 10.1007/s12094-017-1763-6. Epub 2017 Oct 30.

SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017)

M Martínez-Garcia  1 , J Álvarez-Linera  2 , C Carrato  3 , L Ley  4 , R Luque  5 , X Maldonado  6 , M Martínez-Aguillo  7 , L M Navarro  8 , M A Vaz-Salgado  9 , M Gil-Gil  10
Affiliations
Practice Guideline

SEOM clinical guidelines for diagnosis and treatment of glioblastoma (2017)

M Martínez-Garcia et al. Clin Transl Oncol. 2018 Jan.

Abstract

Glioblastoma (GB) is the most common brain malignancy and accounts for over 50% of all high-grade gliomas. Radiotherapy (RT) with concomitant and adjuvant temozolomide (TMZ) chemotherapy is the current standard of care for patients with newly diagnosed GB up to age 70. Recently, a new standard of care has been adopted for elderly patients (≥ 65 years) based on short course of RT and TMZ. Several clinically relevant molecular markers that assist in diagnosis and prognosis have recently been identified. The treatment for recurrent GB is not well defined, and decision-making is usually based on prior strategies as well as several clinical and radiological factors. The presence of neurologic deficits and seizures can significantly impact quality of life.

Keywords: Diagnosis; Glioblastoma; Guidelines; Treatment.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Figures

Fig. 1
Fig. 1
Treatment algorithm for glioblastoma in progression after RT. CT chemotherapy, STR stereotactic radiosurgery, TMZ temozolomide
See this image and copyright information in PMC

References

    1. Galceran J, Ameijide A, Carulla M, Mateos A, Quirós JR, Rojas D, et al. Cancer incidence in Spain, 2015. Clin Transl Oncol. 2017;16:1–27. - PubMed
    1. Grade Definitions. US Preventive Services Task Force. 2016. https://www.uspreventiveservicestaskforce.org/Page/Name/grade-definitions.
    1. Ryken TC, Aygun N, Morris J, Schweizer M, Nair R, Spracklen C, et al. The role of imaging in the management of progressive glioblastoma: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2014;118(3):435–460. doi: 10.1007/s11060-013-1330-0. - DOI - PubMed
    1. Fouke SJ, Benzinger T, Gibson D, Ryken TC, Kalkanis SN, Olson JJ. The role of imaging in the management of adults with diffuse low grade glioma: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2015;125(3):457–479. doi: 10.1007/s11060-015-1908-9. - DOI - PubMed
    1. Stupp R, Brada M, van den Bent MJ, Tonn J-C, Pentheroudakis G, ESMO Guidelines Working Group High-grade glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(suppl 3):93–101. doi: 10.1093/annonc/mdu050. - DOI - PubMed

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