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. 2017 Nov;58(11):1187-1190.

Evaluation of the sterility of single-dose medications used in a multiple-dose fashion

Elizabeth P Martin  1 , Jean Mukherjee  1 , Claire R Sharp  1 , Virginia B Sinnott-Stutzman  1
Affiliations

Evaluation of the sterility of single-dose medications used in a multiple-dose fashion

Elizabeth P Martin et al. Can Vet J. 2017 Nov.

Abstract
in English, French

Bacterial proliferation was evaluated in single-dose medications used in a multi-dose fashion and when medications were intentionally inoculated with bacteria. Of 5 experimentally punctured medications, 1 of 75 vials (50% dextrose) became contaminated. When intentionally inoculated, hydroxyethyl starch and heparinized saline supported microbial growth. Based on these findings, it is recommended that hydroxyethyl starch and heparinized saline not be used in a multi-dose fashion.

Évaluation de la stérilité des médicaments à dose unique utilisés pour plusieurs doses. On a évalué la prolifération bactérienne dans les médicaments à dose unique utilisés pour plusieurs doses et lorsque les médicaments sont intentionnellement inoculés avec des bactéries. Parmi les cinq médicaments ayant subi une ponction expérimentale, 1 des 75 flacons (50 % dextrose) a été contaminé. Lorsqu’ils étaient inoculés intentionnellement, l’hydroxyéthylcellulose et le soluté physiologique hépariné supportaient la croissance microbienne. En se basant sur ces résultats, il est recommandé que l’hydroxyéthylcellulose et le soluté physiologique hépariné ne soient pas utilisés pour plusieurs doses.(Traduit par Isabelle Vallières).

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Conflict of interest statement

Use of this article is limited to a single copy for personal study. Anyone interested in obtaining reprints should contact the CVMA office (hbroughton@cvma-acmv.org) for additional copies or permission to use this material elsewhere.

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