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Review
. 2011 Dec 27:1:28-44.
doi: 10.15256/joc.2011.1.4. eCollection 2011.

Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium

Alessandro Nobili  1 , Silvio Garattini  1 , Pier Mannuccio Mannucci  2
Affiliations
Review

Multiple diseases and polypharmacy in the elderly: challenges for the internist of the third millennium

Alessandro Nobili et al. J Comorb. .

Abstract

The pattern of patients admitted to internal medicine wards has dramatically changed in the last 20-30 years. Elderly people are now the most rapidly growing proportion of the patient population in the majority of Western countries, and aging seldom comes alone, often being accompanied by chronic diseases, comorbidity, disability, frailty, and social isolation. Multiple diseases and multimorbidity inevitably lead to the use of multiple drugs, a condition known as polypharmacy. Over the last 20-30 years, problems related to aging, multimorbidity, and polypharmacy have become a prominent issue in global healthcare. This review discusses how internists might tackle these new challenges of the aging population. They are called to play a primary role in promoting a new, integrated, and comprehensive approach to the care of elderly people, which should incorporate age-related issues into routine clinical practice and decisions. The development of new approaches in the frame of undergraduate and postgraduate training and of clinical research is essential to improve and implement suitable strategies meant to evaluate and manage frail elderly patients with chronic diseases, comorbidity, and polypharmacy. Journal of Comorbidity 2011;1:28-44.

Keywords: adverse drug events; aging; geriatrics; internal medicine; multimorbidity; polypharmacy.

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Conflict of interest statement

None declared.

References

    1. Beeson PB, Maulitz RC. Grand rounds: one hundred years of internal medicines. In: Maulitz RC, Long DC, editors. The inner history of internal medicine. Philadelphia: University of Pennsylvania Press; 1988. pp. 15–54.
    1. Kucharz EJ. Internal medicine: yesterday, today, and tomorrow. Part I. Origin and development: the historical perspective. Eur J Intern Med. 2003;14(3):205–8. - PubMed
    1. Kucharz EJ. Internal medicine: yesterday, today, and tomorrow. Part II. Definition and development in the 20th century. Eur J Intern Med. 2003;14(4):272–4. - PubMed
    1. European Federation of Internal Medicine. Just what is an internist? An identikit of the specialist in the disease of adults composed of six thumbnail definitions. Vnitr Lek. 2001;47(6):414–7. - PubMed
    1. Rozman C. Current and future status of internal medicine. 2005. Available from: www.icim.intramed.net/english/documentos.htm [Last accessed Nov 16, 2011]

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