Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep;18(3):191-196.
doi: 10.7181/acfs.2017.18.3.191. Epub 2017 Sep 26.

Nonsyndromic Multiple Basal Cell Carcinomas

Dong Hwi Kim  1 , Hyo Sun Ko  1 , Young Joon Jun  1
Affiliations

Nonsyndromic Multiple Basal Cell Carcinomas

Dong Hwi Kim et al. Arch Craniofac Surg. 2017 Sep.

Abstract

Basal cell carcinoma (BCC) comprising several lesions is not uncommon, but nonsyndromic multiple BCCs with parotid invasion are rare entities. We present two cases of multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis. In Case 1, a 79-year-old female presented with multiple skin lesions on the face and left hand. All lesions were completely removed by surgery. The pathologic results showed lesions consistent with BCC and some lesions consistent with actinic keratosis. After 8 months, the patient presented with skin lesions in bilateral temporal areas and left cheek area. Surgical excision of the lesions was performed, and the biopsy results were squamous cell carcinoma in situ and actinic keratosis. In Case 2, a 43-year-old woman presented with multiple skin lesions on the face, scalp, right chest, abdomen and right leg. All lesions were completely removed by surgery. Pathologic evaluation confirmed the diagnosis of BCC. BCC is rarely metastatic, but it can lead to severe disfiguration or destruction. It is important to diagnose and treat BCC at an early stage.

Keywords: Basal cell carcinoma, multiple; Basal cell carcinoma, nonsyndromic; Skin neoplasms.

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Case 1. Preoperative photography shows that the lesions (red circles) were located on (A) forehead, (B) left temple (C, D, E) posterior auricular areas, (D) right cheek, and (F) left hand.
Fig. 2
Fig. 2. Case 1. (A, B) Facial magnetic resonance imaging showing that the right posterior auricular basal cell carcinoma (red arrows) was in direct contact with the parotid gland.
Fig. 3
Fig. 3. Case 1. (A) Immediate postoperative clinical photograph. (B) A 7-month follow-up photograph.
Fig. 4
Fig. 4. Case 1. Strands of basal cell carcinoma (BCC) are directly adhered to the parotid gland, and extend to the parotid tissue located at the left bottom of the photograph (H&E, ×20).
Fig. 5
Fig. 5. Case 2. Preoperative photography shows that the lesions were located on the (A) face (red circle), (B) scalp (yellow circle), and (C, D) abdomen.
See this image and copyright information in PMC

References

    1. Zak-Prelich M, Narbutt J, Sysa-Jedrzejowska A. Environmental risk factors predisposing to the development of basal cell carcinoma. Dermatol Surg. 2004;30(2 Pt 2):248–252. - PubMed
    1. McNaughton SA, Marks GC, Green AC. Role of dietary factors in the development of basal cell cancer and squamous cell cancer of the skin. Cancer Epidemiol Biomarkers Prev. 2005;14:1596–1607. - PubMed
    1. Alghamdi Y. Skin tags as a presenting sign of basal cell nevus syndrome in three sisters of the same family. Ann Saudi Med. 2008;28:132–134.
    1. Lu Y, Zhu HG, Ye WM, Zhang MB, He D, Chen WT. A new mutation of PTCH gene in a Chinese family with nevoid basal cell carcinoma syndrome. Chin Med J (Engl) 2008;121:118–121. - PubMed
    1. Farley RL, Manolidis S, Ratner D. Aggressive basal cell carcinoma with invasion of the parotid gland, facial nerve, and temporal bone. Dermatol Surg. 2006;32:307–315. - PubMed

LinkOut - more resources