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Comment
. 2017 Nov 1;595(21):6785-6787.
doi: 10.1113/JP275145.

Reply from Vladimir V. Matchkov and Christian Aalkjaer

Vladimir V Matchkov  1 , Christian Aalkjaer  1
Affiliations
Comment

Reply from Vladimir V. Matchkov and Christian Aalkjaer

Vladimir V Matchkov et al. J Physiol. .
No abstract available

Keywords: in vivo; mesenteric artery; noradrenaline; perivascular nerves; vascular resistance; vasoconstriction.

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Figures

Figure 1
Figure 1. Low plasma noradrenaline concentration (∼15 nm) relaxed the principle arteries while the topical application of the same concentration of noradrenaline did not
Higher noradrenaline concentration (∼200 nm) constricted the principle arteries when applied either systemically or topically. The experimental set‐up was as described previously (Nyvad et al. 2017). (A) Blood pressure was measured by carotid artery catheter in rats anaesthetized with ketamine and xylazine. Noradrenaline was injected intravenously to achieve plasma concentrations of approximately 15 and 200 nm. (B) Vascular responses to intraluminal noradrenaline were measured as the principle artery diameter changes in the experimental chamber. (C) Topical applications of noradrenaline were made to the chamber to achieve final concentrations of 15 and 200 nm, as indicated. n = 3.
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