Gene-Mediated Chemical Communication in Synthetic Protocell Communities
- PMID: 29091420
- DOI: 10.1021/acssynbio.7b00306
Gene-Mediated Chemical Communication in Synthetic Protocell Communities
Abstract
A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.
Keywords: cell-free expression; communication; enzyme cascade; genetic switches; lipid vesicles; proteinosomes; α-hemolysin.
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