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. 2018 Feb 16;7(2):339-346.
doi: 10.1021/acssynbio.7b00306. Epub 2017 Nov 8.

Gene-Mediated Chemical Communication in Synthetic Protocell Communities

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Gene-Mediated Chemical Communication in Synthetic Protocell Communities

T-Y Dora Tang et al. ACS Synth Biol. .

Abstract

A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.

Keywords: cell-free expression; communication; enzyme cascade; genetic switches; lipid vesicles; proteinosomes; α-hemolysin.

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