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Editorial
. 2017 Nov;102(5):1155-1157.
doi: 10.1189/jlb.3CE0717-273R.

Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor

Steven D Douglas  1   2 , Sergei Spitsin  3
Affiliations
Editorial

Editorial: Gateway to monocyte entry into the brain: CXCR7, the new orchestra conductor

Steven D Douglas et al. J Leukoc Biol. 2017 Nov.

Abstract

Discussion on the potential role for CXCR7 as a major signaling pathway for CD14+CD16+ monocyte transmigration across the blood brain barrier, and its therapeutic application for NeuroAIDS.

Keywords: CCX771; CXCL12; HIV; chemotaxis.

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Figures

Figure 1.
Figure 1.. CD14+CD16− (classic) and CD14+CD16+ (nonclassic) monocyte migration across BBB.
Whereas CCR2 is expressed on both classic and nonclassic monocytes, CXCR7 is expressed predominantly by nonclassic monocytes [1]. The expression of both CCR2 and CXCR7 is up-regulated on CD14+CD16+ monocytes in HIV-infected patients [1, 6]. The increased transmigration of human CD14+CD16+ (nonclassic) monocytes across the in vitro BBB model is associated with increased CXCR7 expression.
See this image and copyright information in PMC

Comment on

References

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