Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Dec;44(12):1804-1812.
doi: 10.3899/jrheum.160485. Epub 2017 Nov 1.

Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis

Elena Sánchez  1   2 , Ignacio García de la Torre  1   2 , Mónica Sacnún  1   2 , Mario Goñi  1   2 , Guillermo Berbotto  1   2 , Sergio Paira  1   2 , Jorge Luis Musuruana  1   2 , César Graf  1   2 , Alejandro Alvarellos  1   2 , Osvaldo D Messina  1   2 , Alejandra Babini  1   2 , Ingrid Strusberg  1   2 , Juan Carlos Marcos  1   2 , Hugo Scherbarth  1   2 , Alberto Spindler  1   2 , Ana Quinteros  1   2 , Sergio Toloza  1   2 , José Luis C Moreno  1   2 , Luis J Catoggio  1   2 , Guillermo Tate  1   2 , Alicia Eimon  1   2 , Gustavo Citera  1   2 , Antonio Catalán Pellet  1   2 , Gustavo Nasswetter  1   2 , Mario H Cardiel  1   2 , Pedro Miranda  1   2 , Francisco Ballesteros  1   2 , Jorge A Esquivel-Valerio  1   2 , Marco A Maradiaga-Ceceña  1   2 , Eduardo M Acevedo-Vásquez  1   2 , Conrado García García  1   2 , Teresa Tusié-Luna  1   2 , Bernardo A Pons-Estel  1   2 , Marta E Alarcón-Riquelme  3   4 ; GENAR Study
Collaborators, Affiliations
Free article

Effects of Amerindian Genetic Ancestry on Clinical Variables and Therapy in Patients with Rheumatoid Arthritis

Elena Sánchez et al. J Rheumatol. 2017 Dec.
Free article

Abstract

Objective: To define whether Amerindian genetic ancestry correlates with clinical and therapeutic variables in admixed individuals with rheumatoid arthritis (RA) from Latin America.

Methods: Patients with RA (n = 1347) and healthy controls (n = 1012) from Argentina, Mexico, Chile, and Peru were included. Samples were genotyped for the Immunochip v1 using the Illumina platform. Clinical data were obtained through interviews or the clinical history.

Results: Percentage of Amerindian ancestry was comparable between cases and controls. Morning stiffness (p < 0.0001, OR 0.05), rheumatoid factor (RF; p < 0.0001, OR 0.22), radiographic changes (p < 0.0001, OR 0.05), and higher number of criteria were associated with lower Amerindian ancestry after Bonferroni correction. Higher Amerindian ancestry correlated only with weight loss (pBonferroni < 0.0001, OR 2.85). Increased Amerindian ancestry correlated with higher doses of azathioprine (p < 0.0001, OR 163.6) and sulfasalazine (p < 0.0001, OR 48.6), and inversely with methotrexate (p = 0.001, OR 0.35), leflunomide (p = 0.001, OR 0.16), and nonsteroidal antiinflammatory drugs (pBonferroni = 0.001, OR 0.37). Only the presence of RF and weight loss were modified after confounders adjustment.

Conclusion: Amerindian ancestry protects against most major clinical criteria of RA, but regarding the association of RF with increased European ancestry, age, sex, and smoking are modifiers. Ancestry also correlates with the therapeutic profiles.

Keywords: ADMIXTURE; AMERINDIAN; LATIN AMERICAN; RHEUMATOID ARTHRITIS; SMOKING.

PubMed Disclaimer

MeSH terms