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Observational Study
. 2017 Oct 21;23(39):7160-7167.
doi: 10.3748/wjg.v23.i39.7160.

Characteristics and outcomes of cholangiocarcinoma by region in Thailand: A nationwide study

Roongruedee Chaiteerakij  1 , Wirichada Pan-Ngum  2 , Kittiyod Poovorawan  3 , Ngamphol Soonthornworasiri  2 , Sombat Treeprasertsuk  4 , Kamthorn Phaosawasdi  5
Affiliations
Observational Study

Characteristics and outcomes of cholangiocarcinoma by region in Thailand: A nationwide study

Roongruedee Chaiteerakij et al. World J Gastroenterol. .

Abstract

Aim: To identify the potential risk factors of cholangiocarcinoma, we determined the characteristics of cholangiocarcinoma patients among 5 different regions of Thailand.

Methods: All patients diagnosed with cholangiocarcinoma between 2008 and 2013 were identified using the Nationwide Hospital Admission Data registry (n = 39421). Baseline characteristics, comorbidities and survival were abstracted.

Results: The annual incidence during the study period was stable in all regions. Most patients lived in the Northeast (62.8%), followed by the North (16.9%), Central (12.3%), Bangkok (5.4%), and South (n = 2.6%) regions (P < 0.0001). Significantly more cholangiocarcinoma patients had diabetes, cirrhosis, and chronic viral hepatitis B/C infection than non-cholangiocarcinoma participants (diabetes: 11.42% vs 5.28%; cirrhosis: 4.81% vs 0.92%; hepatitis B: 0.74% vs 0.12%; and hepatitis C: 0.50% vs 0.10%, P < 0.0001 for all, respectively). The overall 1-year mortality rate was 81.7%, with a stable trend over time.

Conclusion: Diabetes and chronic liver diseases may be associated with cholangiocarcinoma in the Thai population.

Keywords: Bile duct cancer; Epidemiology; Liver fluke infection; Population-based study.

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Conflict of interest statement

Conflict-of-interest statement: The authors hereby declare no personal or professional conflicts of interest regarding any aspects of this study.

Figures

Figure 1
Figure 1
Northeast region had the greatest number of cholangiocarcinoma cases, followed by the North and Central regions.
See this image and copyright information in PMC

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