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. 2016 Nov 2;3(5):539-544.
doi: 10.1200/JGO.2016.006411. eCollection 2017 Oct.

Use of Palliative Cisplatinum for Advanced Cervical Cancer in a Resource-Poor Setting: A Case Series From Kenya

Elkanah Orang'o  1 , Peter Itsura  1 , Philip Tonui  1 , Hellen Muliro  1 , Barry Rosen  1 , Luc van Lonkhuijzen  1
Affiliations

Use of Palliative Cisplatinum for Advanced Cervical Cancer in a Resource-Poor Setting: A Case Series From Kenya

Elkanah Orang'o et al. J Glob Oncol. .

Abstract

Purpose: To evaluate the effectiveness and feasibility of cisplatinum for palliative treatment of advanced cervical cancer in a resource-poor setting.

Methods: An observational case series is reported from a university teaching hospital in Kenya. All women presenting with advanced cervical cancer and planned for palliative cisplatinum therapy from 2010 to 2014 were included. Women were treated with cisplatinum 50 mg/m2 every 4 weeks in an outpatient setting. Data on tumor stage and symptoms control were prospectively collected in an electronic database. The main outcome measure was control of symptoms such as bleeding, discharge, and pain.

Results: Of the women who originally presented with bleeding, 62% reported improvement in this symptom, 31.3% reported the bleeding completely stopped, 58% had improvement of their vaginal discharge, and 20.5% reported complete resolution. Of the women who presented with pain, 54% reported improvement; 30.9% reported pain had completely resolved. After each treatment cycle, approximately 30% of patients did not return for their next treatment.

Conclusion: Cisplatinum as palliative treatment of advanced cervical cancer is feasible in a resource-poor setting and leads to effective symptom control. However, unknown barriers may inhibit women from returning for regular treatment.

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Conflict of interest statement

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family Member, Inst = My Institution. Relationships may not relate to the subject matter of this manuscript. For more information about ASCO's conflict of interest policy, please refer to www.asco.org/rwc or ascopubs.org/jco/site/ifc. Elkanah Orang'oNo relationship to disclosePeter ItsuraNo relationship to disclosePhilip TonuiNo relationship to discloseHellen MuliroNo relationship to discloseBarry RosenTravel, Accommodations, Expenses: Intuitive Surgical, da Vinci SurgeryLuc van LonkhuijzenNo relationship to disclose

Figures

Fig 1
Fig 1
Palliative cisplatinum for advanced cervical cancer in Kenya. Response to treatment.
See this image and copyright information in PMC

References

    1. International Agency for Research on Cancer: GLOBOCAN 2012: Estimated cancer incidence and mortality worldwide in 2012. http://globocan.iarc.fr/
    1. Ministry of Public Health and Sanitation and Ministry of Medical Services: National cervical cancer prevention program. Strategic plan 2012-2015. http://www.iedea-ea.org/joomla/attachments/article/304/National%20Cervic....
    1. Osman M. The role of neoadjuvant chemotherapy in the management of locally advanced cervix cancer: a systematic review. Oncol Rev. 2014;8:250. - PMC - PubMed
    1. Basile S, Angioli R, Manci N, et al: Gynecological cancers in developing countries: The challenge of chemotherapy in low-resources setting. Int J Gynecol Cancer 16:1491-1497, 2006. - PubMed
    1. Garces AH, Mora PA, Alves FV, et al. First-line paclitaxel and carboplatin in persistent/recurrent or advanced cervical cancer: A retrospective analysis of patients treated at Brazilian National Cancer Institute. Int J Gynecol Cancer 23:743-748, 2013. - PubMed

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