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. 1989 Jan 1;169(1):345-50.
doi: 10.1084/jem.169.1.345.

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

L M Sollid  1 , G Markussen, J Ek, H Gjerde, F Vartdal, E Thorsby
Affiliations

Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer

L M Sollid et al. J Exp Med. .

Abstract

Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.

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References

    1. Nature. 1988 Apr 28;332(6167):845-50 - PubMed
    1. Nature. 1987 Oct 15-21;329(6140):599-604 - PubMed
    1. J Immunol. 1987 Nov 1;139(9):2993-5 - PubMed
    1. Tissue Antigens. 1988 Apr;31(4):204-10 - PubMed
    1. J Exp Med. 1988 Sep 1;168(3):1181-6 - PubMed

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