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Review
. 2017 Nov 2;8(1):242.
doi: 10.1186/s13287-017-0697-9.

A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction

Chi Miao  1 , Mingming Lei  1 , Weina Hu  1 , Shuo Han  1 , Qi Wang  2
Affiliations
Review

A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction

Chi Miao et al. Stem Cell Res Ther. .

Abstract

Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is among the most serious health threats today. Bone marrow mesenchymal stem cells (BMSCs), with their capacity for multidirectional differentiation, low immunogenicity, and high portability, can serve as ideal seed cells in cardiovascular disease therapy. In this review, we examine recent literature concerning the application of BMSCs for the treatment of MI and consider the following aspects: activity of transplanted cells, migration and homing of BMSCs, immunomodulatory and anti-inflammatory effects of BMSCs, anti-fibrotic activity of BMSCs, the role of BMSCs in angiogenesis, and differentiation of BMSCs into cardiomyocyte-like cells and endothelial cells. Each aspect is complementary to the others and together they promote the repair of cardiomyocytes by BMSCs after MI. Although transplantation of BMSCs has enabled new options for MI treatment, the critical issue we must now address is the reduced viability of transplanted BMSCs due to inadequate blood supply, poor nourishment of cells, and generation of free radicals. More clinical trials are needed to prove the therapeutic potential of BMSCs in MI.

Keywords: Bone marrow mesenchymal stem cells; Myocardial infarction; Regeneration; Transplantation.

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The authors declare that they have no competing interests.

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References

    1. Khan I, Ali A, Akhter MA, et al. Epac-Rap1-activated mesenchymal stem cells improve cardiac function in rat model of myocardial infarction. Cardiovasc Ther. 2017;35(2). doi:10.1111/1755-5922.12248. - PubMed
    1. Khan I, Ali A, Akhter MA, et al. Preconditioning of mesenchymal stem cells with 2,4-dinitrophenol improves cardiac function in infarcted rats. Life Sci. 2016;162:60–9. doi: 10.1016/j.lfs.2016.08.014. - DOI - PubMed
    1. Rodrigo SF, Ramshorst JV, Hoogslag GE, et al. Intramyocardial injection of autologous bone marrow-derived ex vivo expanded mesenchymal stem cells in acute myocardial infarction patients is feasible and safe up to 5 years of follow-up. J Cardiovasc Transl Res. 2013;6(5):816–25. doi: 10.1007/s12265-013-9507-7. - DOI - PMC - PubMed
    1. Lee JW, Lee SH, Youn YJ, et al. A randomized, open-label, multicenter trial for the safety and efficacy of adult mesenchymal stem cells after acute myocardial infarction. J Korean Med Sci. 2014;29(1):23–31. doi: 10.3346/jkms.2014.29.1.23. - DOI - PMC - PubMed
    1. Chullikana A, Majumdar AS, Gottipamula S, et al. Randomized, double-blind, phase I/II study of intravenous allogeneic mesenchymal stromal cells in acute myocardial infarction. Cytotherapy. 2015;17(3):250–61. doi: 10.1016/j.jcyt.2014.10.009. - DOI - PubMed

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