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Editorial
. 2018 Jan;29(1):2-4.
doi: 10.1681/ASN.2017080881. Epub 2017 Nov 2.

Glomerular Disease Pathology in the Era of Proteomics: From Pattern to Pathogenesis

Mark Haas  1
Affiliations
Editorial

Glomerular Disease Pathology in the Era of Proteomics: From Pattern to Pathogenesis

Mark Haas. J Am Soc Nephrol. 2018 Jan.
No abstract available

Keywords: Immunology and pathology; glomerular disease; renal biopsy.

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Figures

Figure 1.
Figure 1.
Documented (left panels) and potential (right panels) uses for proteomic analysis in the study of glomerular diseases. (Top left panel) Amyloid nephropathy (Congo red stain, polarized). (Middle left panel) C3 GN with a membranoproliferative pattern (Jones silver methenamine stain). (Bottom left panel) FGN (electron micrograph showing deposits composed of nonbranching fibrils at the outer [epithelial] aspect of the glomerular basement membrane). (Bottom right panel) Secondary membranous nephropathy (direct immunofluorescence with fluorescein-conjugated anti-IgG; note the segmental distribution of the glomerular capillary wall deposits that is more typical of secondary than primary membranous lesions). (Middle right panel) Early recurrent FSGS in a renal allograft (electron micrograph showing nearly complete podocyte foot process effacement). (Top right panel) Infection-related (postinfectious) GN (electron micrograph showing the characteristic hump-like subepithelial deposits). The image in the center is one of a mass spectrum.
See this image and copyright information in PMC

Comment on

References

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