Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Nov 2;19(12):84.
doi: 10.1007/s11912-017-0637-y.

A Metabolic Therapy for Malignant Glioma Requires a Clinical Measure

Zachary Corbin  1 , Daniel Spielman  2 , Lawrence Recht  3
Affiliations
Review

A Metabolic Therapy for Malignant Glioma Requires a Clinical Measure

Zachary Corbin et al. Curr Oncol Rep. .

Abstract

Cancers are "reprogrammed" to use a much higher rate of glycolysis (GLY) relative to oxidative phosphorylation (OXPHOS), even in the presence of adequate amounts of oxygenation. Originally identified by Nobel Laureate Otto Warburg, this hallmark of cancer has recently been termed metabolic reprogramming and represents a way for the cancer tissue to divert carbon skeletons to produce biomass. Understanding the mechanisms that underlie this metabolic shift should lead to better strategies for cancer treatments. Malignant gliomas, cancers that are very resistant to conventional treatments, are highly glycolytic and seem particularly suited to approaches that can subvert this phenotype.

Keywords: 1-C13 pyruvate DNP MRS; Aerobic glycolysis; Malignant glioma; Metabolic reprogramming; Metabolic therapy; Warburg effect.

PubMed Disclaimer

References

    1. J Obstet Gynaecol Res. 2004 Jun;30(3):193-6 - PubMed
    1. J Neurochem. 2007 Dec;103(6):2449-61 - PubMed
    1. Prostate. 2010 Sep 15;70(13):1388-94 - PubMed
    1. Science. 1956 Feb 24;123(3191):309-14 - PubMed
    1. Cancer Cell. 2011 Jan 18;19(1):17-30 - PubMed

LinkOut - more resources