Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017:1000:261-280.
doi: 10.1007/978-981-10-4304-8_15.

MicroRNAs Mediate Beneficial Effects of Exercise in Heart

Yihua Bei  1 , Lichan Tao  2 , Dragos Cretoiu  3   4 , Sanda Maria Cretoiu  3   4 , Junjie Xiao  5
Affiliations
Review

MicroRNAs Mediate Beneficial Effects of Exercise in Heart

Yihua Bei et al. Adv Exp Med Biol. 2017.

Abstract

MicroRNAs (miRNAs, miRs), a group of small non-coding RNAs, repress gene expressions at posttranscriptional level in most cases and are involved in cardiovascular physiology and disease pathogenesis. Increasing evidence has proved that miRNAs are potential regulators of exercise induced cardiac growth and mediate the benefits of exercise in a variety of cardiovascular diseases. In this chapter, we will review the regulatory effects of miRNAs in cardiac adaptations to exercise, and summarize their cardioprotective effects against myocardial infarction, ischemia/reperfusion injury, heart failure, diabetic cardiomyopathy, atherosclerosis, hypertension, and pulmonary hypertension. Also, we will introduce circulating miRNAs in response to acute and chronic exercise. Therefore, miRNAs may serve as novel therapeutic targets and potential biomarkers for cardiovascular diseases.

Keywords: Cardiovascular diseases; Exercise; MicroRNA.

PubMed Disclaimer

Publication types

LinkOut - more resources