Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Feb 1;14(2):420-429.
doi: 10.1080/21645515.2017.1392422. Epub 2017 Dec 15.

Global economic evaluation of oral cholera vaccine: A systematic review

Siew Li Teoh  1 , Surachai Kotirum  1   2 , Raymond C W Hutubessy  3 , Nathorn Chaiyakunapruk  1   4   5   6
Affiliations

Global economic evaluation of oral cholera vaccine: A systematic review

Siew Li Teoh et al. Hum Vaccin Immunother. .

Abstract

World Health Organization recommends oral cholera vaccine (OCV) to prevent and control cholera, but requires cost-effectiveness evidence. This review aimed to provide a critical appraisal and summary of global economic evaluation (EE) studies involving OCV to guide future EE study. Full EE studies, published from inception to December 2015, evaluating OCV against cholera disease were included. The included studies were appraised using WHO guide for standardization of EE of immunization programs. Out of 14 included studies, almost all (13/14) were in low- and middle-income countries. Most studies (11/14) evaluated mass vaccination program. Most of the studies (9/14) incorporated herd protective effect. The most common influential parameters were cholera incidence, OCV coverage, herd protection and OCV price. OCV vaccination is likely to be cost-effective when targeted at the population with high-risk of cholera and poor access to health care facilities when herd protection effect is incorporated and OCV price is low.

Keywords: Economic Evaluation; Oral Cholera Vaccine; Systematic Review.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Flow of study selection.
See this image and copyright information in PMC

References

    1. World Health Organization Oral cholera vaccines in mass immunization campaigns: Guidance for planning and use. 2010.
    1. World Health Organization Editorial note: Cholera, a public health priority. Weekly epidemiological record. 2015;40(90):517-44. - PubMed
    1. World Health Organization. Cholera, 2014. Weekly epidemiological record. 2015;40(90):517-44.
    1. Ali M, Nelson AR, Lopez AL, Sack DA. Updated global burden of cholera in endemic countries. PLoS Negl Trop Dis. 2015;9(6):e0003832. doi:10.1371/journal.pntd.0003832. PMID:26043000 - DOI - PMC - PubMed
    1. Ali M, Lopez AL, You Y, et al.. The global burden of cholera. Bulletin of the World Health Organization. 2012;90(3):209-18. doi:10.2471/BLT.11.093427. PMID:22461716 - DOI - PMC - PubMed

Publication types

Substances