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Review
. 2017 Nov 3;9(11):153.
doi: 10.3390/cancers9110153.

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina  1   2 , Enric Espel  3   4
Affiliations
Review

Role of LFA-1 and ICAM-1 in Cancer

Manuel Reina et al. Cancers (Basel). .

Abstract

The lymphocyte function-associated antigen-1 (LFA-1) (also known as CD11a/CD18 and αLβ₂), is just one of many integrins in the human body, but its significance is derived from its exclusive presence in leukocytes. In this review, we summarize the studies relating LFA-1 and its major ligand ICAM-1 (or CD54) with cancer, through the function of lymphocytes and myeloid cells on tumor cells. We consider how LFA-1 mediates the interaction of leukocytes with tumors and the role of ICAM-1 in tumor dynamics, which can be independent of its interaction with LFA-1. We also offer a more detailed examination of the role of LFA-1 within B-cell chronic lymphocytic leukemia. Finally, we discuss the role that exosomes harboring LFA-1 play in tumor growth and metastasis.

Keywords: cancer metastasis; chronic lymphocytic leukemia; exosomes; tumor microenvironment.

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Conflict of interest statement

The authors declare no conflicts of interest.

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