Estrogen Effects on Wound Healing

Huann-Cheng Horng^{1

2

3}, Wen-Hsun Chang^{4

5

6}, Chang-Ching Yeh^{7

8

9}, Ben-Shian Huang^{10

11

12}, Chia-Pei Chang^{13

14}, Yi-Jen Chen^{15

16

17}, Kuan-Hao Tsui^{18

19

20}, Peng-Hui Wang^{21

22

23

24}

Affiliations

¹ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
² Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
³ Institute of BioMedical Informatics, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
⁴ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁵ Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁶ Department of Nursing, National Yang-Ming University, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁷ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. ccyeh39@gmail.com.
⁸ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
⁹ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
¹⁰ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹¹ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹² Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹³ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
¹⁴ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
¹⁵ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁶ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁷ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁸ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. khtsui60@gmail.com.
¹⁹ Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan. khtsui60@gmail.com.
²⁰ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung County 900, Taiwan. khtsui60@gmail.com.
²¹ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²² Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²³ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²⁴ Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan. phwang@vghtpe.gov.tw.

PMID: 29099810
PMCID: PMC5713294
DOI: 10.3390/ijms18112325

Review

Estrogen Effects on Wound Healing

Huann-Cheng Horng et al. Int J Mol Sci. 2017.

. 2017 Nov 3;18(11):2325.

doi: 10.3390/ijms18112325.

Authors

Affiliations

¹ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
² Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
³ Institute of BioMedical Informatics, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
⁴ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁵ Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁶ Department of Nursing, National Yang-Ming University, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
⁷ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. ccyeh39@gmail.com.
⁸ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
⁹ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
¹⁰ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹¹ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹² Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
¹³ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
¹⁴ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
¹⁵ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁶ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁷ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
¹⁸ Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. khtsui60@gmail.com.
¹⁹ Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan. khtsui60@gmail.com.
²⁰ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung County 900, Taiwan. khtsui60@gmail.com.
²¹ Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²² Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²³ Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
²⁴ Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan. phwang@vghtpe.gov.tw.

PMID: 29099810
PMCID: PMC5713294
DOI: 10.3390/ijms18112325

Abstract

Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

Keywords: estrogen; estrogen receptor; wound healing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

1. Su W.H., Cheng M.H., Lee W.L., Tsou T.S., Chang W.H., Chen C.S., Wang P.H. Nonsteroidal anti-inflammatory drugs for wounds: Pain relief or excessive scar formation? Mediat. Inflamm. 2010;2010:413238. doi: 10.1155/2010/413238. - DOI - PMC - PubMed
1. Wang Y.W., Liou N.H., Cherng J.H., Chang S.J., Ma K.H., Fu E., Liu J.C., Dai N.T. siRNA-targeting transforming growth factor-β type I receptor reduces wound scarring and extracellular matrix deposition of scar tissue. J. Investig. Dermatol. 2014;134:2016–2025. doi: 10.1038/jid.2014.84. - DOI - PubMed
1. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int. J. Mol. Sci. 2017;18:606. doi: 10.3390/ijms18030606. - DOI - PMC - PubMed
1. Butzelaar L., Ulrich M.M., Mink van der Molen A.B., Niessen F.B., Beelen R.H. Currently known risk factors for hypertrophic skin scarring: A review. J. Plast. Reconstr. Aesthet. Surg. 2016;69:163–169. doi: 10.1016/j.bjps.2015.11.015. - DOI - PubMed
1. Hofer M., Hoferová Z., Falk M. Pharmacological modulation of radiation damage. Does it exist a chance for other substances than hematopoietic growth factors and cytokines? Int. J. Mol. Sci. 2017;18:1385. doi: 10.3390/ijms18071385. - DOI - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Estrogen Effects on Wound Healing

Affiliations

Estrogen Effects on Wound Healing

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources