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Comment
. 2017 Nov 2;21(5):564-565.
doi: 10.1016/j.stem.2017.10.008.

At Last: Gene Editing in Human Embryos to Understand Human Development

Albert Ruzo  1 , Ali H Brivanlou  2
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At Last: Gene Editing in Human Embryos to Understand Human Development

Albert Ruzo et al. Cell Stem Cell. .
Free article

Abstract

Our understanding of early human development is typically based on inference from animal models, which may not fully recapitulate human embryonic features. As proof of concept, Fogarty et al. (2017) used CRISPR/Cas9 to genetically ablate the OCT4 gene in human preimplantation embryos and found key differences from its function in model systems.

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  • Genome editing reveals a role for OCT4 in human embryogenesis.
    Fogarty NME, McCarthy A, Snijders KE, Powell BE, Kubikova N, Blakeley P, Lea R, Elder K, Wamaitha SE, Kim D, Maciulyte V, Kleinjung J, Kim JS, Wells D, Vallier L, Bertero A, Turner JMA, Niakan KK. Fogarty NME, et al. Nature. 2017 Oct 5;550(7674):67-73. doi: 10.1038/nature24033. Epub 2017 Sep 20. Nature. 2017. PMID: 28953884 Free PMC article.

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