A Missing Link to Vitamin B12 Metabolism

Abstract

Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B₁₂ levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B₁₂ metabolism and the immunomodulatory metabolite, itaconate.