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. 2017 Aug 23;8(44):77990-77998.
doi: 10.18632/oncotarget.20400. eCollection 2017 Sep 29.

An association between the endothelial nitric oxide synthase gene G894T polymorphism and premature coronary artery disease: a meta-analysis

Boqian Zhu #  1 , Xinmin Si #  2 , Yaoyao Gong #  2 , Gaoliang Yan  1 , Dong Wang  1 , Yong Qiao  1 , Bo Liu  1 , Jiantong Hou  1 , Chengchun Tang #  1
Affiliations

An association between the endothelial nitric oxide synthase gene G894T polymorphism and premature coronary artery disease: a meta-analysis

Boqian Zhu et al. Oncotarget. .

Abstract

Previous epidemiological studies have suggested that genetic factors are more likely to influence the development of premature coronary artery disease (CAD) than disease in older patients. Several studies have evaluated the association between the G894T polymorphism located in an exon of endothelial nitric oxide synthase (eNOS) and the risk of premature CAD. However, the findings were inconsistent. Thus, we performed a meta-analysis to clarify the association; we conducted both overall and subgroup analyses. Odds ratios and 95% confidence interval were calculated to evaluate the association between the G894T polymorphism and the risk of premature CAD. Overall analysis revealed a significant association. Subgroup analysis in terms of ethnicity revealed a significant association, in all models evaluated, between the G894T polymorphism and susceptibility to premature CAD in mixed population. In contrast, no such association was evident in Caucasians and Asians. On further subgroup analysis based on the premature CAD subtypes, we found that the G894T polymorphism was correlated with premature myocardial infarction (MI) but not with premature CAD without MI. In conclusion, we confirmed that the eNOS G894T polymorphism is a risk factor for premature CAD, particularly in those suffering premature MI.

Keywords: G894T; Glu298Asp; endothelial nitric oxide synthase; polymorphism; premature coronary artery disease.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart of the literature search
Figure 2
Figure 2. Forest plots of the ORs with 95% CIs, using different genetic models, for the association between the G894T polymorphism and the risk of CAD in patients stratified by ethnicity
(A) Allelic, (B) dominant, and (C) recessive models.
Figure 3
Figure 3. Forest plots of the ORs with 95% CIs, using different genetic models, for the association between the G894T polymorphism and the risk of CAD in patients stratified by type of disease
(A) Allelic, (B) dominant, and (C) recessive models.
Figure 4
Figure 4. The effect of each study on the overall outcome, as revealed by omitting each study one at a time when various genetic models were evaluated
(A) Allelic, (B) dominant, and (C) recessive models.
Figure 5
Figure 5. The funnel plots used to assess publication bias
(A) Allelic, (B) dominant, and (C) recessive models.
See this image and copyright information in PMC

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