Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jan;143(1):78-81.
doi: 10.1001/archpedi.1989.02150130088021.

Pulmonary function in preterm infants following treatment with intravenous indomethacin

A N Krauss  1 , N Fatica, B S Lewis, R Cooper, H T Thaler, C Cirrincione, J O'Loughlin, A Levin, M A Engle, P A Auld
Affiliations

Pulmonary function in preterm infants following treatment with intravenous indomethacin

A N Krauss et al. Am J Dis Child. 1989 Jan.

Abstract

Pulmonary function tests, including measurements of arterial blood gas levels, total pulmonary compliance, and arterial-alveolar oxygen ratios, were performed in 38 ventilator-dependent preterm infants with respiratory distress syndrome who weighed less than 1500 g at birth. Twenty-seven had a physiologically significant patent ductus arteriosus (PDA). Twelve were assigned at random to receive three doses of intravenous indomethacin, 0.2 mg/kg per dose, on the fourth day of life. This treatment resulted in ductal closure in seven infants by the seventh day of life. Another concurrently observed group of 15 infants with PDA received no indomethacin. A third group of 11 infants lacked evidence of a PDA. Pulmonary function in the infants who received indomethacin did not differ significantly from that in the other two groups.

PubMed Disclaimer

MeSH terms