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. 2017 Nov;6(8):726-730.
doi: 10.1530/EC-17-0262.

Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

Paolo G Arduino  1 , Dora Karimi  2 , Federico Tirone  3 , Veronica Sciannameo  4 , Fulvio Ricceri  4 , Marco Cabras  2 , Alessio Gambino  2 , Davide Conrotto  2 , Stefano Salzano  3 , Mario Carbone  2 , Roberto Broccoletti  2
Affiliations

Evidence of earlier thyroid dysfunction in newly diagnosed oral lichen planus patients: a hint for endocrinologists

Paolo G Arduino et al. Endocr Connect. 2017 Nov.

Abstract

The association between oral lichen planus (OLP) and hypothyroidism has been debated with conflicting results: some authors detected a statistically significant association between these two, while others did not confirm it. The aim of this study was to evaluate the thyroid status in patients with newly diagnosed OLP to test the null hypothesis that thyroid disease is not associated with an increased incidence of oral lesions, with a prospective case-control approach. A total of 549 patients have been evaluated, of whom 355 were female. Odds ratio (OR) and 95% confidence intervals (CIs) were obtained. Patients suffering from thyroid diseases were associated with an almost 3-fold increased odds of having OLP (OR 2.85, 95% CI: 1.65-4.94), after adjusting this analysis for age, gender, body mass index, smoking status, diabetes, hypertension and hepatitis C infection. It would be appropriate to further investigate the possible concomitance of OLP among patients with thyroid disorder; endocrinologists should be aware of this association, especially because OLP is considered a potentially malignant oral disorder.

Keywords: OLP; risk factor; thyroid disease.

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Figures

Figure 1
Figure 1
Analysis between differences in thyroid disease positivity for OLP patients vs patients with no oral lesions, adjusted for age, gender, BMI, smoke, diabetes, hypertension and HCV infection.
See this image and copyright information in PMC

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