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Review
. 2018 May;26(5):436-446.
doi: 10.1016/j.tim.2017.10.002. Epub 2017 Nov 2.

A Call to Arms: Quest for a Cryptococcal Vaccine

Marley C Caballero Van Dyke  1 , Floyd L Wormley Jr  2
Affiliations
Review

A Call to Arms: Quest for a Cryptococcal Vaccine

Marley C Caballero Van Dyke et al. Trends Microbiol. 2018 May.

Abstract

Cryptococcosis remains a significant cause of morbidity and mortality world-wide, particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically available to treat or prevent cryptococcosis. In this review, we provide a rationale to support continued investment in Cryptococcus vaccine research, potential challenges that must be overcome along the way, and a literature review of the current progress underway towards developing a vaccine to prevent cryptococcosis.

Keywords: Cryptococcus; Cryptococcus gattii; Cryptococcus neoformans; cryptococcal vaccine; cryptococcosis.

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Figures

Figure 1
Figure 1. Cellular Location of Potential Cryptococcal Vaccine Targets and/or Components
Various strategies to develop an effective anti-cryptococcal vaccine include targeting the capsule [–70], engineering recombinant proteins of mannoproteins [–90], targeting or utilization of β-glucans [71, 109], targeting melanin [73], engineering mutant chitosan deficient strains [77], and utilizing cryptococcal glycolipids as vaccine candidates or adjuvants [52, 110, 115]. GXM: glucuronoxylomannan; GalXM: galactoxylomannan; GalCer: galactosylceramide; GlcCer: glucosylceramide.
See this image and copyright information in PMC

References

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