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Review
. 2017 Nov 1;9(11):1201.
doi: 10.3390/nu9111201.

Epigenetic Regulatory Mechanisms Induced by Resveratrol

Guilherme Felipe Santos Fernandes  1   2 , Gabriel Dalio Bernardes Silva  3 , Aline Renata Pavan  4 , Diego Eidy Chiba  5 , Chung Man Chin  6 , Jean Leandro Dos Santos  7
Affiliations
Review

Epigenetic Regulatory Mechanisms Induced by Resveratrol

Guilherme Felipe Santos Fernandes et al. Nutrients. .

Abstract

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).

Keywords: DNA methyltransferase; SIRT1; epigenetic targets; histone acetyltransferase; histone deacetylase; resveratrol.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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