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Review
. 2017;8(1):7.
doi: 10.1186/s12645-017-0030-4. Epub 2017 Oct 26.

Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles

Eudald Casals #  1 , Muriel F Gusta #  1 , Macarena Cobaleda-Siles  1 , Ana Garcia-Sanz  1 , Victor F Puntes  1   2   3
Affiliations
Review

Cancer resistance to treatment and antiresistance tools offered by multimodal multifunctional nanoparticles

Eudald Casals et al. Cancer Nanotechnol. 2017.

Abstract

Chemotherapeutic agents have limited efficacy and resistance to them limits today and will limit tomorrow our capabilities of cure. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours. In front of this, multimodality has appeared as a promising strategy to overcome resistance. In this context, the use of nanoparticle-based platforms enables many possibilities to address cancer resistance mechanisms. Nanoparticles can act as carriers and substrates for different ligands and biologically active molecules, antennas for imaging, thermal and radiotherapy and, at the same time, they can be effectors by themselves. This enables their use in multimodal therapies to overcome the wall of resistance where conventional medicine crash as ageing of the population advance. In this work, we review the cancer resistance mechanisms and the advantages of inorganic nanomaterials to enable multimodality against them. In addition, we comment on the need of a profound understanding of what happens to the nanoparticle-based platforms in the biological environment for those possibilities to become a reality.

Keywords: Cancer resistance; Inorganic nanoparticles; Multifunctional; Multimodality; Resistance to treatment.

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Figures

Fig. 1
Fig. 1
Schematic representation of different cancer treatment modalities that can be integrated in a single NP-based platform
Fig. 2
Fig. 2
Different advantages enabled by a NP platform for a multimodal approach to address cancer resistance
See this image and copyright information in PMC

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