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. 2017 Nov 16;53(92):12457-12460.
doi: 10.1039/c7cc05703b.

Palladium catalyzed direct aliphatic γC(sp3)-H alkenylation with alkenes and alkenyl iodides

Neetipalli Thrimurtulu  1 , Salman Khan, Soham Maity, Chandra M R Volla, Debabrata Maiti
Affiliations

Palladium catalyzed direct aliphatic γC(sp3)-H alkenylation with alkenes and alkenyl iodides

Neetipalli Thrimurtulu et al. Chem Commun (Camb). .

Abstract

The catalytic alkenylation of the unactivated distal γC(sp3)-H bonds of aliphatic acids with simple acrylates and vinyl iodides is described. This method allows for the introduction of an alkene group into aliphatic acid derivatives in the form of activated olefins and vinyl iodides. Notably, olefination with vinyl iodides provides access to a wide range of challenging γ-vinyl acid derivatives with aliphatic olefin functionality introduced in a diastereoselective manner.

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