Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2017 Oct:24 Suppl 2:25-43.
doi: 10.1111/jvh.12760.

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

H L Y Chan  1   2 , C J Chen  3 , O Omede  4 , J Al Qamish  5 , K Al Naamani  6 , A Bane  7   8 , S S Tan  9 , M Simonova  10 , I Cardenas  11 , M Derbala  12 , O Akin  4 , R O Phillips  13 , M K Abdelmageed  14 , M Abdulla  15 , D Adda  16   17 , A Al Baqali  18 , N Al Dweik  12 , K Al Ejji  12 , I Al Ghazzawi  19 , S Al Kaabi  12 , M Al Sadadi  15 , J Al Salman  15 , M AlBadri  12 , S A Al-Busafi  20 , H E Al-Romaihi  21 , W Ampofo  22 , K Antonov  23 , C Anyaike  4 , F Arome  24 , S Blach  25 , M M Borodo  26   27 , S M Brandon  25 , B Bright  28 , M T Butt  12 , D S Chen  29 , P J Chen  30 , R N Chien  31 , W L Chuang  32 , D Cuellar  33 , A A Elbardiny  21 , C Estes  25 , E Farag  21 , J Fung  34 , I Gamkrelidze  25 , V Garcia  35 , J Genov  36 , Z Ghandour  37 , M Ghuloom  15 , B Gomez  38 , J Gunter  25 , J Habeeb  15 , O Hajelssedig  12 , W Hamoudi  39   40 , S M Himatt  21 , I Hrstic  41 , C C Hu  31 , C F Huang  32 , Y T Hui  42 , R Jahis  43 , D Jelev  23 , A K John  12 , K S Kaliaskarova  44   45 , Y Kamel  12   46 , J H Kao  47 , J Khamis  15 , H Khattabi  48 , I Khoudri  49 , A Konysbekova  50   51 , I Kotzev  52 , M S Lai  53 , W C Lao  54 , J Layden  55 , M H Lee  56 , O Lesi  57   58 , M Li  59 , A Lo  2 , C K Loo  60 , B Lukšić  61 , A Maaroufi  49 , A O Malu  62 , L Mateva  23 , R Mitova  36 , R Mohamed  63 , M Morović  64 , K Murphy  25 , B Mustapha  65 , A Nersesov  66 , E Ngige  4 , R Njouom  67 , O Njoya  68 , D Nonković  69 , S Obekpa  24   62 , S Oguche  70   71   72 , E E Okolo  73 , C Omuemu  74 , P Ondoa  75   76 , O Opare-Sem  13 , S Owusu-Ofori  77 , Y N Prokopenko  45 , H Razavi  25 , D Razavi-Shearer  25 , K Razavi-Shearer  25 , B Redae  8   78 , T Reic  79 , T Rinke de Wit  80 , C Rios  81 , S Robbins  25 , L R Roberts  82 , S J Sanad  37 , J D Schmelzer  25 , M Sharma  12 , T H Su  47 , K Sultan  12 , K Tchernev  83 , O T Y Tsang  84 , S Tsang  85 , C Tzeuton  86 , S Ugoeze  87 , B Uzochukwu  88 , R Vi  45   89 , A Vince  90 , H U Wani  12 , V W S Wong  1   91 , A Workneh  92   93 , R Yacoub  12 , K I Yesmembetov  94 , M Youbi  49 , M F Yuen  95 , H Nde  25
Affiliations
Comparative Study

The present and future disease burden of hepatitis C virus infections with today's treatment paradigm: Volume 4

H L Y Chan et al. J Viral Hepat. 2017 Oct.

Abstract

Factors influencing the morbidity and mortality associated with viremic hepatitis C virus (HCV) infection change over time and place, making it difficult to compare reported estimates. Models were developed for 17 countries (Bahrain, Bulgaria, Cameroon, Colombia, Croatia, Dominican Republic, Ethiopia, Ghana, Hong Kong, Jordan, Kazakhstan, Malaysia, Morocco, Nigeria, Qatar and Taiwan) to quantify and characterize the viremic population as well as forecast the changes in the infected population and the corresponding disease burden from 2015 to 2030. Model inputs were agreed upon through expert consensus, and a standardized methodology was followed to allow for comparison across countries. The viremic prevalence is expected to remain constant or decline in all but four countries (Ethiopia, Ghana, Jordan and Oman); however, HCV-related morbidity and mortality will increase in all countries except Qatar and Taiwan. In Qatar, the high-treatment rate will contribute to a reduction in total cases and HCV-related morbidity by 2030. In the remaining countries, however, the current treatment paradigm will be insufficient to achieve large reductions in HCV-related morbidity and mortality.

Keywords: HCV; diagnosis; disease burden; epidemiology; hepatitis C; incidence; mortality; prevalence; treatment.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources