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. 1979 Aug;76(8):4075-8.
doi: 10.1073/pnas.76.8.4075.

Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides

L B Townsend, K H Schram, J Beránek

Evaluation of a common receptor-complement concept for predicting the antileukemic activity of nucleosides

L B Townsend et al. Proc Natl Acad Sci U S A. 1979 Aug.

Abstract

The triangulation arrangement of one nitrogen and two oxygen atoms proposed as a requirement for antileukemic activity involving a "common receptor-complement feature" has been reevaluated specifically as it applies to nucleosides. This re-evaluation has resulted in a rejection of the "receptor-complement feature" as a working model for the a priori design of nucleosides as compounds active against leukemia L-1210.

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