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. 2017 Dec 1;27(23):5221-5224.
doi: 10.1016/j.bmcl.2017.10.047. Epub 2017 Oct 20.

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Aaron Smith  1 , Zhi-Jie Ni  1 , Daniel Poon  1 , Zilin Huang  1 , Zheng Chen  1 , Qiong Zhang  1 , Laura Tandeske  1 , Hanne Merritt  1 , Kevin Shoemaker  1 , John Chan  1 , Susan Kaufman  1 , Kay Huh  1 , Jeremy Murray  1 , Brent A Appleton  1 , Sandra W Cowan-Jacob  2 , Clemens Scheufler  2 , Takanori Kanazawa  1 , Johanna M Jansen  1 , Darrin Stuart  1 , Cynthia M Shafer  3
Affiliations

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors

Aaron Smith et al. Bioorg Med Chem Lett. .

Abstract

A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAFV600E. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

Keywords: Kinase; MAPK; RAF.

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