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. 2017 May 23;8(45):79315-79322.
doi: 10.18632/oncotarget.18105. eCollection 2017 Oct 3.

Significance of the thrombo-inflammatory status-based novel prognostic score as a useful predictor for in-hospital mortality of patients with type B acute aortic dissection

Dongze Li  1 , Lei Ye  1 , Jing Yu  2 , Lixia Deng  2 , Lianjing Liang  1 , Yan Ma  3 , Lei Yi  4 , Zhi Zeng  1 , Yu Cao  1 , Zhi Wan  1
Affiliations

Significance of the thrombo-inflammatory status-based novel prognostic score as a useful predictor for in-hospital mortality of patients with type B acute aortic dissection

Dongze Li et al. Oncotarget. .

Abstract

Background: Inflammation and thrombosis are associated with development and progression of acute aortic dissection (AAD). The aim of this study was to assess the prognostic significance of Simplified Thrombo-Inflammatory Prognostic Score (sTIPS), in patients with early phase type B AAD.

Methods: We retrospectively reviewed 491 patients with type B AAD between November 2012 and September 2015. sTIPS was calculated from the white blood cell count (WBC) and mean platelet volume to platelet count (MPV/PC) ratio, at the time of admission. Patients with both, WBC > 10 (109/L) and MPV/PC ratio > 7.5 (102fL/109L-1) were assigned a score of 2, while patients with high levels of either one or none of the above markers, were assigned scores of 1 and 0 respectively. Multivariable Cox regression analyses were used to investigate the associations between the score and hospital survival.

Results: Of the 491 type B AAD patients included in this analysis, 24 patients (4.9%) died during hospitalization. Kaplan-Meier analysis revealed that the cumulative mortality was significantly higher in patients with higher sTIPS (P = 0.001). Multivariable Cox regression analysis further indicated that higher sTIPS was a strong predictor of in-hospital mortality after eliminating all confounding factors (sTIPS 2: hazard ratio 4.704, 95%; confidence interval [CI] 1.184-18.685; P = 0.028; sTIPS 1: hazard ratio 1.918, 95%; CI 1.134-3.537; P = 0.045).

Conclusions: sTIPS at admission was a useful tool for stratifying the risk in type B AAD patients, for outcomes such as in-hospital mortality in the early phase.

Keywords: acute aortic dissection; inflammation; prognosis; thrombosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1. A. the short-term mortality in different thrombo-inflammatory prognostic score (sTIPS) patients with type B acute aortic dissection; B. Kaplan-Meier analysis survival curve according to different sTIPS in patients with type B acute aortic dissection (0 score:, 1 score:, 2 score:)
Figure 2
Figure 2. A. Kaplan-Meier analysis survival curve according to different thrombo-inflammatory prognostic score (sTIPS) in patients with type B acute aortic dissection receiving medication therapy
B. Kaplan-Meier analysis survival curve according to different sTIPS in patients with type B acute aortic dissection receiving endovascular therapy. (0 score:formula image, 1 score:formula image, 2 score:formula image).
See this image and copyright information in PMC

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