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Review
. 2017 Oct 29;9(11):1188.
doi: 10.3390/nu9111188.

Therapeutic Versatility of Resveratrol Derivatives

Waqas Nawaz  1 , Zhongqin Zhou  2 , Sa Deng  3 , Xiaodong Ma  4 , Xiaochi Ma  5 , Chuangang Li  6 , Xiaohong Shu  7   8
Affiliations
Review

Therapeutic Versatility of Resveratrol Derivatives

Waqas Nawaz et al. Nutrients. .

Abstract

Resveratrol, a natural phytoalexin, exhibits a remarkable range of biological activities, such as anticancer, cardioprotective, neuroprotective and antioxidant properties. However, the therapeutic application of resveratrol was encumbered for its low bioavailability. Therefore, many researchers focused on designing and synthesizing the derivatives of resveratrol to enhance the bioavailability and the pharmacological activity of resveratrol. During the past decades, a large number of natural and synthetic resveratrol derivatives were extensively studied, and the methoxylated, hydroxylated and halogenated derivatives of resveratrol received particular more attention for their beneficial bioactivity. So, in this review, we will summarize the chemical structure and the therapeutic versatility of resveratrol derivatives, and thus provide the related structure activity relationship reference for their practical applications.

Keywords: pharmacological activity; resveratrol; resveratrol derivatives; structure-activity relationship.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structures of trans-resveratrol (3,5,4′-trihydroxystilbene) and its cis-isomer. (A) trans-resveratrol; (B) cis-resveratrol.
Figure 2
Figure 2
Chemical structures of methoxylated derivatives of resveratrol. (A) Pterostilbene; (B) Trimethoxystilbene; (C) Tetramethoxystilbene; (D) Pentamethoxystilbene.
Figure 3
Figure 3
Chemical structure of selected hydroxylated resveratrol derivatives. (A) Hydroxystilbene; (B) dihydroxystilbene; (C) Tetrahydroxystilbene; (D) Pentahydroxystilbene; (E) Hexahydroxystilbene.
Figure 4
Figure 4
Chemical structure of selected halogenated resveratrol derivatives. (A) 4′-Bromoresveratrol; (B) 3,4,5-Trimethoxy-4′-bromo-trans-stilbene (BTS); (C) 3,4,5-Trimethoxy-4′-bromo-cis-stilbene (BCS); (D) 2-Chlororesveratrol; (E) 4-Iodoresveratrol.
See this image and copyright information in PMC

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