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. 2018 Mar;49(1):1-8.
doi: 10.1007/s12029-017-0021-z.

Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review

William Paul Skelton 4th  1 , Hiral Parekh  2 , Jason S Starr  2 , Jose Trevino  3 , Jessica Cioffi  3 , Steven Hughes  3 , Thomas J George Jr  4
Affiliations

Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review

William Paul Skelton 4th et al. J Gastrointest Cancer. 2018 Mar.

Abstract

Introduction: Pancreatic cancer is often diagnosed at late stages, where disease is either locally advanced unresectable or metastatic. Despite advances, long-term survival is relatively non-existent.

Discussion: This review article discusses clinical factors commonly encountered in practice that should be incorporated into the decision-making process to optimize patient outcomes, including performance status, nutrition and cachexia, pain, psychological distress, medical comorbidities, advanced age, and treatment selection.

Conclusion: Identification and optimization of these clinical factors could make a meaningful impact on the patient's quality of life.

Keywords: Cachexia; Nutrition; Pain; Pancreatic cancer; Performance status; Personalized treatment.

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